Rise of azithromycin resistance: a study on antibiotic resistance pattern in culture positive cases of typhoid fever in a tertiary hospital in Delhi

Background: Typhoid fever is a public health problem with high disease burden in India. The prevalence of multidrug resistance typhoid has nearly doubled from 1999 to 2005. against Fluoroquinlones very due indiscriminate use and an increased Azithromycin, one the first line antibiotics used being observed. This study will evaluate current trend antibiotic among cases observed tertiary care hospital.Methods: A retrospective record-based analysis was carried out for all culture-proven admitted teaching hospital Delhi. blood culture reports patients 1 January 2016 31 December 2017 were analyzed. Only culture-positive which isolated S. typhi Paratyphi included study. sensitivity pattern done using disc diffusion method data regards following analysed: ciprofloxacins, Amikacin, Gentamycin, Amoxicillin, Cefepime, Cefixime, Cotrimoxazole, Ceftriaxone.Results: incidence positive total number cultures received 1.84%. Of these 118 cultures, 101 (85.6%) typhi, 17 (14.4%) A. 54 (45.8%) sensitive antibiotics. testing revealed resistance: Azithromycin (21.2%), ciprofloxacin (16.9%), Gentamycin (10.2%), Amoxicillin (8.5%), Cefepime (1.7%), Cefixime (4%), Cotrimoxazole (4.2%), Ceftriaxone (0.8%).Conclusions: There increase bacilli. regular yearly assessment should be undertaken by developing registry that accumulates hospitals diagnostic centers.